Table Of Content
In ciliary body and retinal wall, levels of proinflammatory enzymes iNOS and COX-2 and activation of PKC and NF-κB were also reduced in groups that underwent benfotiamine treatment [13]. Benfotiamine has also proven to be neuroprotective and beneficial in suppresing inflammation in mouse model of tauopathy [21]. Specifically, it reduced the expression of iNOS, COX-2, TNF-α, IL-1β and NF-κB p65 in transgenic mice that overexpress tau gene that has P301S mutation that leads to frontotemporal dementia in men. Additionally, benfotiamine mitigated oxidative stress and mitochondrial dysfunction and activated Nrf2/ARE pathway in this model, showing its potential to be used in treatment for diseases with tau pathology [21]. Vitamin B7 (biotin or vitamin H) is a cofactor for five carboxylases that catalyze steps in fatty acid, glucose, and amino acid metabolism. Biotin also plays roles in histone modification, cell signaling, and gene regulation [25].
Examining how pain could play a direct protective role in the gut
Not suprisingly, anti-inflammatory actions of benfotiamine have been shown in diverse in vivo and in vitro model systems. Experiments in cell culture have been helpful in elucidating possible mechanisms of benfotiamine effects and anti-inflammatory effects have been shown in cultures of macrophages [14,15], microglia [18], dendritic cells [86]. In macrophages benfotiamine reduced the expression of proinflammatory cytokines and chemokines, induced with lipopolysacharide (LPS) treatment. Inflammation markers - inducible nitric oxide synthase and cyclooxygenase 2, as well as their products NO and PGE2 were also reduced under benfotiamine treatment [14]. These effects were contributed to benfotiamine's action on transcription factors NF-κB and Egr-1, arachidonic acid pathway, protein kinase C and members of MAPK signaling cascade – p38, ERK1/2, SAPK/JNK [14,15].
Zinc
However, comprehensive studies are lacking, which preclude any recommendation for screening of selenium or riboflavin. Thompson et al. evaluated the association between AA and vitamin D in a prospective study. Survey data encompassing lifestyle and medical history from 55,929 women in the Nurses’ Health Study were investigated. The authors found that there was no significant association between dietary, supplemental, or total vitamin D intake and risk of developing AA [69]. Vitamin B12 is necessary for DNA synthesis, neurological function, and red blood cell formation [22]. The active forms of B12 are called methylcobalamin and 5-deoxyadenosylcobalamin.
Telogen Effluvium/Androgenetic Alopecia
Benfotiamine: Uses, Benefits, Side Effects, Dosage - Verywell Health
Benfotiamine: Uses, Benefits, Side Effects, Dosage.
Posted: Tue, 21 Feb 2023 08:00:00 GMT [source]
Diabetes involves high blood sugar levels, which can damage blood vessels and cause diabetic neuropathy. Supplement use should be individualized and vetted by a healthcare professional, such as a registered dietitian, pharmacist, or healthcare provider. Because it has antioxidant and anti-inflammatory properties, benfotiamine may also be helpful for diabetic neuropathy (nerve pain) and Alzheimer's disease. On the whole, it’s important that you speak with your doctor about any symptoms you’re experiencing. A dermatologist can provide a proper diagnosis, and select a personalized treatment that will help restore health to you hair and scalp. According to Healthline, other common types of alopecia include traction alopecia, telogen effluvium, alopecia areata, central centrifugal cicatricial alopecia (CCCA), and lichen planopilaris (LPP).
The data of the present study revealed that administration of ISO resulted in upregulation of myocardial contents of caspase-8 and p53 in ISO-A and ISO-B groups compared to the normal group. The aforementioned results are in agreement with the work of other investigators [47–49]. Previous literature verified the initiation of apoptosis in the myocardium after ISO administration via caspase-8,9 and FAS genes [50,51]. This evidence could be related to the marked elevation of oxidative stress markers, depletion of endogenous antioxidants and stimulation of inflammatory as well as apoptotic pathways as a result of β-stimulation [21].
Prescription oral medications
Micronutrients, including vitamins and trace minerals, are therefore crucial components of our diet [5]. According to Stewart and Gutherie [6], in 1497 Vasco de Gamma recorded the deaths of 100 of his 160 sailors due to scurvy and 300 years later James Lind linked scurvy with vitamin C deficiency, noting skin hemorrhage and hair loss [6]. In protein-energy malnutrition, skin and hair changes are prominent, as seen, for example in children with kwashiorkor, marasmus, and marasmic-kwashiorkor conditions [7].
By Regina C. Windsor, MPH, RDNRegina Windsor, MPH, RDN, is an editor for Verywell Health. Her expertise includes population health, data analysis and synthesis, nutrition and dietetics, publishing, and education. She is a systems-oriented thinker with a passion for exploration and authentic connection. When choosing a supplement, look for third-party tested products and consult a healthcare provider, registered dietitian nutritionist (RD or RDN), or pharmacist.
Tick season is expanding: Protect yourself against Lyme disease
The elevation of the cardiac antioxidant activities of SOD and GPx after 14 days of ISO induction could justify the decline in MDA content in ISO-B group. Thus, the increase in antioxidant enzyme levels after treatment with ISO could be explained by the adaptive response towards oxidative stress. Androgenetic alopecia (AGA), telogen effluvium (TE) are two common types of hair loss.
The Reasons Why You Can Get a Vitamin B Rash, Hives or Flush - Livestrong
The Reasons Why You Can Get a Vitamin B Rash, Hives or Flush.
Posted: Sat, 26 Sep 2015 15:14:46 GMT [source]
In addition, our group found that benfotiamine mitigated morphological alterations of BV-2 cells, induced by LPS stimulation. Microglia are extremely mobile cells that quickly change their shape in order to exert their functions, and rearrangement of the cytoskeletal proteins, specifically actin microfilaments, is crucial in this process [87]. Muller-Krebs et al., also found that benfotiamine restores reorganization of actin cytoskeleton of podocytes that were exposed to high glucose concentrations [88]. Cytoskeleton reorganization in activation of microglia has been attributed to activation of MAPK signaling cascade, specifically ERK1/2, p38 and JNKs were found to be partly responsible for morphological activation of microglia [89]. JNKs catalyze phoshporylation of proteins in the cytoskeleton [89], and induce actin expression by actvating c-Jun [90].
Anyone with medical concerns should always discuss their diet and any food supplement use with their medical team to check for any potential negative interactions. In conclusion, benfotiamine has shown beneficial effects in treatment of various disorders, most notably thiamine deficiency, diabetes, alcoholism and neurodegenerative diseases including Alzheimerˈs disease. These effects have been investigated in a plethora of in vitro and in vivo models. Importantly, results of clinical trials investigating benfotiamine in Alzheimerˈs disease, diabetes and alcoholism show promising results, but warrant further studies with larger number of patients.
Although often referred to as a lipid-soluble analog of thiamine, benfotiamine is virtually insoluble in hydrophobic and organic solvents [4]. When administered orally, benfotiamine is dephosphorylated by alkaline phosphatases in the intestine to S-benzoylthiamine, which is lipophilic and can cross cell membranes. S-Benzoylthiamine diffuses through the intestinal epithelium into the bloodstream, where it is converted to free thiamine by erythrocytes [5].
The procedure was performed along with the manufacturer's instructions and the results were expressed as U/mg protein where the sensitivity using this assay was up to 40 U/l. Two major health concerns that can result from thiamine deficiency include Wernicke-Korsakoff syndrome and beriberi. Pyruvic acid is a byproduct of your body’s inability to convert food into fuel due to a lack of vitamin B1. Symptoms of beriberi include difficulty breathing; irregular eye movement and heart function; pain; vomiting; loss of sensation or feeling; and decreased alertness. A clinical trial in patients with ovarian cancer undergoing chemotherapy showed a significant decrease in hair loss and other gastrointestinal symptoms in patients receiving selenium supplementation, as compared with controls. The authors concluded that ingesting selenium is a supportive element in chemotherapy [119].
Biotin supplementation has been successful in the treatment of brittle nails [137]. In a double-blinded placebo-controlled trial published in 1981, where the investigators administered 220 mg zinc gluconate twice per day for 3 months to AA subjects, there was no improvement of AA after zinc supplementation [127]. On the other hand, another study involving 15 patients with AA who took 50 mg zinc gluconate for 12 weeks showed good results in nine of the 15 subjects [128]. The recommended dietary allowance for selenium is 55 μg daily for individuals aged ≥ 14 years in U.S. populations. The availability of selenium in a variety of foods, such as meat, vegetables, and nuts, are sufficient to meet the daily requirement [120]. Symptoms of acute or chronic selenium toxicity include nausea, vomiting, nail brittleness and discolorations, hair loss, fatigability, irritability, and foul breath odor [120].
If you often wear a hairstyle like braids or a tight bun that puts prolonged strain or stress on the hair follicle, that can cause a type of permanent hair loss called traction alopecia. In the recent clinical trial on LITFULO, more than 700 patients with alopecia were enrolled from 18 nations. Every participant had experienced hair loss on half their scalp for less than a decade, and half the cohort had experienced total scalp hair loss. ISO groups showed marked cardiac muscle damage together with loss of nuclei as well as areas of infarction and pyknotic nuclei with cardiac lesion scores of 5 and 4 for ISO-A and ISO-B treated groups, respectively.
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